HRS Article:   What's Up, Doc?
 
by Susan Brown, D.V.M.
 
PART TWO: TAKING THE FEAR OUT OF RABBIT ANESTHESIA
 

In part one general anesthetic concepts were discussed. In this column, we will finish with a discussion of the process your pet will go through to undergo general anesthesia for a surgical procedure through the recovery period.
 

Preanesthetic Evaluation

Every rabbit that is going to undergo an anesthetic or surgical procedure should have a thorough physical examination performed. There is no exception to this rule. You would not expect your doctor to put you under anesthesia unless you had been thoroughly examined and you should not expect less for your pet. Depending on the type of procedure being suggested and the age and condition of the rabbit, your veterinarian may suggest certain diagnostic tests.
 
The most common tests include any of the following: a complete blood cell (CBC) count, serum biochemistries, X-rays, ultrasound, ECG and/or urinalysis. Your veterinarian can explain the reason for the tests in each case.
 
*Important: In situations where owners decline recommended preanesthetic/surgical diagnostics, the risk factor for the rabbit may increase because the veterinarian cannot acquire all the needed information to make an informed decision on the suitability of the patient to undergo anesthesia/surgery.
 

Treat/Stabilize Existing Disorders

It is important to stabilize or treat any disorder present at the time of the physical examination, such as dehydration, infections, liver or kidney disorders, heart or lung disease or breathing difficulties prior to the administration of the anesthetic. The most common condition that we see that interferes with anesthesia and surgery is obesity. Obese rabbits are always considered high risk patients due to the possibility of concurrent liver disease (fatty liver) and respiratory problems due to the pressure of excess fat on or in the chest cavity. Unless there is a life-threatening situation that requires immediate surgery, obese rabbits should always go through a weight reduction program prior to anesthesia.
 
*Important: It should be noted that there are rare situations where a preexisting health condition that interferes with safe anesthesia/surgery is not detected in a rabbit. As mentioned previously, we are dealing with complex creatures and all our tests are not infallible. However, the occurrence of such situations when a thorough preanesthetic evaluation is done are extremely uncommon.
 

Anesthetic Induction

Anesthetic induction is the administration of the anesthetic agent(s). Due to the nature of the rabbit's GI tract and the fact that he cannot vomit, it is not necessary to fast a rabbit extensively prior to induction. Some veterinarians prefer to remove the food one to two hours presurgically to make sure the rabbit's mouth is clear of food. As we previously discussed, your rabbit may be given preanesthetic drugs prior to receiving general anesthesia.
 
The general anesthetic is administered either by injection or by inhalation. Induction with gas anesthesia can be accomplished via an anesthetic chamber, a face mask or an endotracheal (ET) tube. The rabbit is maintained under general inhalation anesthesia with either a face mask or ET tube.
 

Anesthetic/Surgical General Procedures

Once your rabbit is unconscious, he or she is placed on a warm pad to help prevent heat loss. In some cases an overhead source of heat is also used. The mouth is cleaned of any food or excessive saliva if necessary. At this time if an ET tube is going to used, it is be placed. The head and chest should be level or slightly elevated to prevent excessive pressure of the abdominal organs against the diaphragm which could interfere with the ease of breathing. If an IV catheter was not placed prior to surgery, it will be placed now that the rabbit is unconscious. Except for short procedures in healthy animals, it is advisable to have an IV catheter in place in case emergency drugs need to be given quickly and to administer fluids. Most rabbits undergoing lengthy surgical procedures will receive IV fluids to prevent dehydration and replace blood loss. It is preferable that the fluids be warm, particularly in lengthy procedures, to help maintain normal body temperature. Emergency drugs should be close at hand. Monitoring devices are attached.
 

Anesthetic Monitoring

There are several parameters that are monitored during an anesthetic/surgical procedure and a variety of monitoring devices that can be used.
 
Respiration - Respiration can be monitored visually by an assistant, through a regular or esophageal stethoscope, by a respiratory monitor (attaches between the ET tube and the anesthetic machine to measure changes in air flow), or by a pulse oximeter (measures oxygen saturation of the blood).
 
Heart Rate/Pulse - The heart rate or pulse can be monitored by a regular or esophageal stethoscope, an ECG machine, a Doppler or a pulse oximeter.
 
Body Temperature - The body temperature is monitored with a rectal thermometer.
 
Reflexes - Monitoring the rabbit's response to certain stimuli helps assess the depth of anesthesia. There are several ways of doing this, but the most commonly used tests are pinching the toe and touching the eye. If the toe is pinched and the rabbit tries to pull its foot away or if the eye is touched and the rabbit tries to blink, the anesthesia is too light. The rabbit may appear to be unconscious, but positive reactions to these tests indicates that it can still feel pain, so the anesthetic will be adjusted accordingly.
 

Postanesthetic Care

Once the procedure is completed your rabbit will enter the recovery period. Inhalant anesthesia is discontinued and he or she will receive oxygen for a few minutes prior to disconnecting the anesthetic machine. The ET tube is removed as your rabbit starts to show signs of awakening. Reflexes are checked with increasingly strong responses indicating recovery from anesthesia. Your rabbit will be moved to a recovery area. It is preferable that this area be quiet but visible to the veterinary staff who are monitoring the recovery.
 
The amount of warmth your rabbit will need during recovery will depend on his or her body temperature at the end of the procedure. It is important to watch the amount of warmth used to prevent hyperthermia. Most rabbits need only a brief period of extra warmth until recovery. Respiration and heart rate continue to be monitored, usually by direct observation and stethoscope, until your rabbit is fully awake.
 

Postanesthetic Care: Analgesia

Although this is primarily a discussion on anesthesia and surgery, we cannot leave out the important aspect of pain control in the rabbit after a painful procedure is performed. As mentioned early on, moderate to severe pain can represent a serious stress to the rabbit and can result in some potentially dangerous consequences. Many years past when we did not understand the full significance of pain management in our pets, including rabbits, a rabbit would often survive a surgical procedure, only to die within the next 36 hours. The old cliche of "the operation was a success, but the patient died" would apply to those situations Analgesics may not always be needed for minor procedures, but should always be used for all major surgeries.
 
Some of these cases would most likely have survived if postsurgical pain had been managed, thereby reducing the stress on the rabbit. You know that if you have had a painful procedure performed  you much prefer pain-alleviating medications to feeling uncomfortable. Rabbits in pain recover more slowly than those not in pain. Analgesics may not always be needed for minor procedures, but should always be used for all major surgeries.
 
The most common analgesics currently used in rabbits include butorphanol, buprenorphine and nonsteroidal anti-inflammatory drugs (NSAIDs) such as banamine, carprofen and ketafen. Aspirin can also be used for mild analgesia. An alternative source of mild to moderate analgesia for chronic pain relief is acupuncture or acupressure.
 

Rabbit Behavior Postanesthesia/Surgery

Your veterinarian should advise you on what specific signs to be aware of in your rabbit after a anesthetic/surgical procedure. Here are some general behaviors that might be observed:
 
*Quiet behavior: Your rabbit may want to sleep and stay quietly in one area. The lack of activity can be caused by residual anesthetic in the body, pain, or medication. Some analgesics have sedative properties and may add to the lethargy. Check with your veterinarian about what you should expect with any drugs that you are giving to your rabbit. If your pet is extremely lethargic, is crying out or appears unable to move normally and sits hunched in one spot, you should contact your veterinarian immediately.
 
*Poor appetite - Your rabbit may not eat or drink at all for the first 24hours after returning home. Analgesics may improve this situation but not completely eliminate it. You may syringe feed your pet a thin slurry of ground pellets or blenderized fresh vegetables mixed with fruit juice once or twice during this period. If your rabbit still refuses to eat after 24 hours, you should contact your veterinarian immediately.
 
*Abnormal or absence of stools - Anesthetic and analgesic agents can alter the motility of the GI tract. In addition, the rabbit may have eaten poorly just prior to and just after surgery, therefore, there may be an absence of stools for a period up to three days after anesthesia/surgery. If stools are present, they may initially be smaller than normal, misshapen or soft. This condition should clear up within three days.

Watery diarrhea should not be present and is cause for immediate concern. Please contact your veterinarian should you have any questions about your rabbit''s stools or urine.
 

Questions to Ask Your Veterinarian

In summary, here are questions that you can ask your veterinarian that cover the areas of concern regarding anesthetic procedures:
 
1. Experience level - Ask about the experience level of the veterinarian regarding rabbits in general and about the procedure in question. Even though he or she may not have had a lot of experience, based on the answers to the other questions here and his or her willingness to work with you, you may decide to go ahead with the procedure.
 
2. Types of anesthetic agents used - You now have a list of anesthetic agents that are commonly used. If your veterinarian is using something else, ask for some type of literature or their experience in using this drug(s) before making your decision. Remember, some information in this article will become outdated in time and new drugs will become available that are not discussed here.
 
3. Explain the anesthetic/surgical procedure - You are entitled to know how your pet is going to be handled through the anesthetic/surgical process. You now have a detailed description of the kinds of things that should be happening to decrease risk. Analgesics can be given prior to or during surgery as well as after surgery to make the recovery period go more smoothly. In particular, find out about preanesthetic evaluation, anesthetic monitoring, recovery monitoring and use of analgesic agents.
 
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Dr. Brown is co-owner of the Midwest Bird & Exotic Animal Hospital.